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CHRIP
Information on Biodegradation and Bioconcentration of the Existing Chemical Substances in the Chemical Risk information platform (CHRIP)
General information:
The Chemical Risk Information Platform (CHRIP) provided by the National Institute of Technology and Evaluation (NITE) in Japan, contains information on the result of biodegradation and bioconcentration tests and the testing condition of Existing Chemical Substances under the Chemical Substances Control Law, according to the official bulletin of METI. This part of CHRIP is to be linked to the Portal.
For reference, other related information, such as related laws and regulations, physical-chemical properties, exposure information and risk assessment information are provided in a database called “TOTAL SEARCH SYSTEM” in CHRIP.
Hazard information:
There is information (data, its judgment and the date of the judgment) on biodegradation and bioconcentration and the testing conditions for target chemical substances.
Search capabilities:
The information is provided through a retrieval system based on chemical substance names, the MITI numbers in the official gazette, the CAS numbers and the data (BCF, BOD, etc) as well as lists of Existing Chemical Substances for which hazard assessments have been performed in Japan.
Maintenance:
National Institute of Technology and Evaluation (NITE)
Peer review:
The results of biodegradation and bioaccumulation tests in this database are reviewed by the Chemical Substances Council.
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EnviChem
Data Bank of Environmental Properties of Chemicals
General information:
EnviChem is a factual database containing test results data on ca. 3000 substances. EnviChem contains data related to the effects, fate and behaviour of chemicals in the environment. The most extensive part of the report is the toxicity data (LC/EC/IC50, LOEC, NOEC etc.) of substances to aquatic organisms. There are also data on physico-chemical properties, degradation, metabolism, bioaccumulation and the effects of the substance to terrestrial species eg. plants and mammals.
The content of EnviChem database is useful to environmental researchers, authorities, hazard assessors and companies dealing with chemicals. Correct interpretation of the core data requires some experience of environmental hazard assessment and chemistry.
Hazard information:
The original aim of EnviChem has been to facilitate the environmental hazard and risk assessment and the environmental classification of chemical substances. EnviChem contains information related to general information, physico-chemical properties, degradation, metabolism, bioaccumulation and the effects of the chemical to terrestrial and aquatic environment. The most extensive part of the report is the toxicity to aquatic organisms.
The data concerning individual substances in EnviChem is divided into the following topics:
- General information
- Physico-chemical properties
- Information about degradation
- Information about metabolism and bioaccumulation
- Effects on terrestrial ecosystem
- Effects on aquatic ecosystem
- References
A typical way of expressing acute lethal toxicity to fish is presented in the following way:
LC50 values to fishes, mg/l :
2.2 96 hr, Brachydanio rerio
0.9 96 hr, flow through, Pimephales promelas
2 96 hr, flow through, Pimephales promelas
0.46 96 hr, flow through, Ictalurus punctatus
0.9 96 hr, static, Lepomis macrochirus
0.35 96 hr, flow through, Perca flavescens
7.3 96 hr, static, Leuciscus idus
EU RA Report 2003
The list of Abbreviations and The list of Species are available at the EnviChem www SEARCH-page.
Search capabilities:
Each dataset is always related to a substance. CAS-numbers or substance names can be used as search keys.
Maintenance:
The EnviChem database is maintained by Finnish Environment Institute (SYKE)
Mailing address:
SYKE-Chemicals Division
Box 140, Helsinki, 00251, Finland
Peer review:
The data in EnviChem has mainly been compiled from scientific publications, handbooks and databases in the field of ecotoxicology. The great majority of the content of EnviChem data has been stored to the data-base between the years 1985-2001. The scientific value of the compiled information has not regularly been assessed by the Finnish Environment Institute and the original published data may not have undergone any systematic peer-review process. The Finnish Environment Institute takes no responsibility for any faults/mistakes in the content of the database.
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ESIS
European chemical substances information system (ESIS)
General information:
ESIS is an IT System which provides information on chemicals, related to:
- EINECS (European Inventory of Existing Commercial Substances),
- ELINCS (European List of Notified Chemical Substances),
- List of EU HPVCs (High Production Volume Chemicals) and LPVCs (Low Production Volume Chemicals) including the EU Producers & Importers
- IUCLID chemical datasets for ca. 2,500 HPVCs (data on toxicity, ecotoxicity and classification and labeling)
- EU Priority substance risk assessment reports
- Harmonised classification and labelling
Hazard information:
For High Production Volume Chemicals, the IUCLID data sets submitted by the manufacturers and importers in the context of Council Regulation (EEC) 793/93 can be downloaded as PDF files as well as IUCLID export files. These contain summaries of available studies on hazard of chemicals for numerous endpoints.
Search capabilities:
For substances listed in EINECS, the site can be queried for chemicals by CAS number, EC number, substance name and molecular formula. Substances listed in ELINCS can also be queried by trade name and registration number.
Queries for hazardous properties are not possible. The IUCLID export files can be downloaded and imported into a local IUCLID installation. Extensive query functions on chemical identifiers and hazard endpoints can be performed with the IUCLID Software.
Maintenance:
European Commission (European Chemicals Bureau)
Peer review:
The EU Priority substance risk assessment reports and the harmonised classification and labelling have undergone a peer-review by government authorities.
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HPVIS
High Production Volume Information System (HPVIS)
General information:
The USEPA High Production Volume Information System (HPVIS) provides access to select health and environmental effects information on chemicals that are manufactured in exceptionally large amounts in the US. Information in this database is submitted through EPA's High Production Volume (HPV) Challenge Program. Sponsor (company/consortium) information, test plans, robust summaries, and EPA and public comments are available in the HPVIS. As of December 2006, HPVIS contains 327 submissions, representing 848 chemical substances, either as a single chemical submission or as a member of a chemical category.
Hazard information:
Sponsors follow the Screening Information Data Set (SIDS), developed by the Organization for Economic Cooperation and Development when submitting data to the HPVIS. HPVIS submissions contain hazard data on up to 50 endpoints organized into four disciplines: physical/chemical properties, environmental fate and pathways, ecotoxicity, and mammalian health effects. Information on use and exposure is also available, if provided by sponsors.
Search capabilities:
HPVIS allows users to search for robust summary information, test plans and new data on high production volume chemicals as they are developed. Searches are provided for Chemical Name or CAS Number, Category Name, Submission Name, Sponsor/Consortium Name, and Submitter Name. Users can use a query tool to create a special report for specific data elements and can also create an endpoint result report and a matrix of individual chemical members of a category to assist in performing a "read-across" analysis for those chemicals in a category for which a result was not reported for a specific endpoint.
Maintenance:
HPVIS is maintained by the United States Environmental Protection Agency.
Peer review:
HPVIS data have been entered from the robust summaries and test plans as submitted by the HPV Challenge Program sponsors. This self-reported information is also available on the USEPA HPV website at http://www.epa.gov/hpv. EPA has verified the data entered into the HPVIS to ensure that they are consistent with the information that was submitted under the HPV Challenge Program. Industry sponsors also have the opportunity to verify their submitted data in the system. EPA plans to assess the quality of the HPV Challenge data following the recommendation of the National Pollution Prevention and Toxics Advisory Committee (http://www.epa.gov/oppt/npptac/pubs/recommendationfeb2005.pdf), but has not yet begun that effort. EPA and public comments on the adequacy of the initial submission by the sponsor are provided as attachments to the submissions.
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HSNO CCID
New Zealand Hazardous Substances and New Organisms Chemical Classification Information Database
General information:
The CCID is a database of chemicals classified by ERMA New Zealand in accordance with the classification criteria specified in the Hazardous Substances (Classification) Regulations 2001. These regulations, under the New Zealand Hazardous Substances and New Organisms Act (HSNO), are based on the UN Globally Harmonised System for Classification and Labelling of Chemicals (GHS).
Hazard information:
Classifications are provided for both the physical hazards (explosiveness, flammability, oxidising capacity, metal corrosiveness) and biological hazards (toxicity, biological corrosiveness and ecotoxicity) of a chemical in accordance with the GHS based HSNO classification criteria.
The HSNO hazard classifications, specified in the Hazardous Substances (Classification) Regulations 2001, are represented by numbers (identifying the class and subclass of hazard), a letter (ranking the hazard) and an associated hazard phrase. For example: 3.1C Flammable liquids: Medium hazard. In general, these HSNO classifications correlate to GHS classification categories.
Search capabilities:
The CCID database can be searched by CAS number or chemical name.
Maintenance:
ERMA New Zealand
Peer review:
Some substances have been classified against the criteria from data obtained from international peer reviewed sources. In other cases substances have been classified by conversion from assigned R phrases. The assignment of classifications has been internally peer reviewed within ERMA New Zealand.
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INCHEM
Chemical Safety Information from Intergovernmental Organizations - INCHEM
General information:
INCHEM provides a single consolidated collection of chemical-safety information from intergovernmental organizations; and rapid electronic access to information on chemicals used throughout the world and which may occur as contaminants in the environment and food. The collection consists of over 8000 documents in full-text format which are available free-of-charge. INCHEM is also available on a CD-ROM for those with poor internet connections.
Hazard information:
The collection includes the established series of the reports of the WHO/FAO Joint Meeting on Pesticide Residues (JMPR), the WHO/FAO Joint Expert Committee on Food Additives (JECFA), IPCS Environmental Health Criteria (EHC), IPCS Concise International Chemical Assessment Documents (CICADs), International Agency of Research on Cancer (IARC) Summaries and Evaluations, IPCS International Safety Cards (ICSC) and IPCS Poisons Information Monographs.
Search capabilities:
INCHEM allows simultaneous free-text searching across all available documents e.g. searching words in titles of documents and/or signs and symptoms of exposure. It also allows searching by chemical name, synonyms and CAS Registry Number. Synonyms used in different languages are searchable.
Maintenance:
INCHEM is maintained collaboratively by the International Programme on Chemical Safety (IPCS) at the World Health Organization and the Canadian Centre for Occupational Health and Safety (CCOHS). INCHEM was developed in the context of the Inter-Organization Programme for the Sound Management of Chemicals (IOMC) with the participation of the Food and Agriculture Organization of the United Nations (FAO); the International Labour Organization (ILO); the Organisation for Economic Cooperation and Development (OECD); the United Nations Institute for Training and Development (UNITAR) and the World Health Organization (WHO).
Peer review:
International peer review is an essential part of the process of preparing the series of intergovernmental reports included in INCHEM. This peer review includes review by government agencies and the expert committees such as those of the WHO and FAO.
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NICNAS PEC
Australian National Industrial Chemicals Notification and Assessment Scheme (NICNAS) Priority Existing Chemical Assessment Reports
General information:
Reports on chemicals assessed as Priority Existing Chemicals under Australia’s National Industrial Chemicals Notification and Assessment Scheme (NICNAS). The scope of the assessments vary and include full risk assessments (covering risks to workers and/or the public and/or the environment), as well as assessments that are not risk assessments but which focus on particular aspects e.g. manufacture, handling, storage, uses, human or environmental exposure in a specific geographical area or in specified circumstances, toxicity/hazards of a chemical.
The reports are comprehensive and provide information on uses and exposure that would be useful to other government or industry hazard assessors and to the general public.
Hazard information:
Full risk assessment reports usually contain information on chemical/physical properties, uses, exposure, kinetics and metabolism, effects on experimental animals and in vitro test systems, human health effects, environmental release, fate and effects, and exposure. They include a human health classification, a section on human and environmental risk characterisation, risk management, and recommendations for safe use. Reports published since 2003 include an appendix containing classification of the chemical under the Globally Harmonised System for Hazard Classification and Communication.
Search capabilities:
The reports are in PDF form and can be searched via the Adobe Acrobat search functions.
Maintenance:
NICNAS
Peer review:
Reports are peer-reviewed by NICNAS and the Australian Government Department of Environment and Water Resources. Some reports or sections of reports are peer-reviewed by independent experts in Australia or overseas. Details of the peer-review process for each report can be found in the Introduction to the report.
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OECD HPV
Organisation for Economic Cooperation and Development (OECD) High Production Volume (HPV) Database
General information:
The status of all HPV chemicals within the process of investigation in the OECD HPV Chemicals Programme is recorded in the OECD HPV Database. It contains the list of all OECD HPV chemicals together with any annotations on each chemical which has been provided by Member countries to the Secretariat. Each chemical is identified as to exactly which stage it is at in the assessment process, and for those chemicals which have been assessed, a link to internet pages where completed assessments can be downloaded is provided.
Hazard information:
The database does not contain structured information on hazards. It contains – for those substances which have been assessed within the OECD HPV Chemicals Programme - a summary of the conclusions on the hazards as well as a link to the full SIDS Initial Assessment Report.
Furthermore, links to internet pages where completed assessments can be downloaded are included for each entry.
Search capabilities:
This database can be queried for chemicals by name, synonym, CAS number as well as their status within the OECD HPV Chemicals
Programme.
Maintenance:
OECD Secretariat in collaboration with OECD member countries
Peer review:
The information on the status of chemicals within the OECD HPV Chemicals Programme is continuously updated by the OECD Secretariat and verified by OECD member countries.
For those substances which have been assessed within the OECD HPV Chemicals Programme, the available summary of the conclusions on the hazards has been reviewed by experts in member countries, industry and environmental NGOs and endorsed by all OECD member countries.
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SIDS IUCLID
Screening Information Data Sets (SIDS) export files in for High Production Volume (HPV) Chemicals in International Uniform Chemical Identification Database (IUCLID) format as maintained by the OECD
General information:
The IUCLID software is the preferred tool for entering data and developing a SIDS Dossier for High Production Volume Chemicals in the OECD HPV Chemicals Programme. For those SIDS Dossiers which were elaborated with the IUCLID software, the IUCLID files (in export format) are available on this site. These export files can be downloaded and then imported into a local IUCLID installation. For information, the corresponding report in PDF format is also available on this site.
Hazard information:
These files contain Robust Study Summaries of all the key studies used in the SIDS Initial Assessment Reports.
Search capabilities:
No queries are possible on this site. The files can be downloaded and imported into a local IUCLID installation. Extensive query functions on chemical identifiers and hazard endpoints can be performed with the IUCLID software.
Maintenance:
OECD
Peer review:
The information on the status of chemicals within the OECD HPV Chemicals Programme is continuously updated by the OECD Secretariat and verified by OECD member countries.
For those substances which have been assessed within the OECD HPV Chemicals Programme, the available summary of the conclusions on the hazards has been reviewed by experts in member countries, industry and environmental NGOs and endorsed by all OECD member countries.
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SIDS UNEP
OECD Initial Assessment Reports for HPV Chemicals including Screening Information Data Sets (SIDS) as maintained by United Nations Environment Programme (UNEP) Chemicals
General information:
This site presents the OECD Initial Assessment Reports that have been processed through the OECD HPV Chemicals Programme.
Hazard information:
The reports are initial hazard assessments and contain hazard information and conclusions on numerous endpoints. All reports are available as PDF files.
Search capabilities:
This site can be queried for chemicals by CAS number. Reports are also listed according to their chemical name. Queries for properties across all posted reports are not possible.
Maintenance:
UNEP Chemicals
Peer review:
The OECD initial assessments published by UNEP Chemicals have been reviewed by experts in OECD member countries, industry and environmental NGOs and endorsed by all OECD member countries.
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